Surfactant-free amorphous solid dispersion with high dissolution for bioavailability enhancement of hydrophobic drugs: a case of quercetin

dissolution rate enhancement of irbesartan using solid dispersion with pegs

Orally Disintegrating Tablets Containing Melt Extruded Amorphous Solid Dispersion of Tacrolimus for Dissolution Enhancement

In order to improve the aqueous solubility and dissolution of Tacrolimus (TAC), amorphous solid dispersions of TAC were prepared by hot melt extrusion with three hydrophilic polymers, Polyvinylpyrrolidone vinyl acetate (PVP VA64), Soluplus® and Hydroxypropyl Cellulose (HPC), at a drug loading of 10% w/w. Molecular modeling was used to determine the miscibility of the drug with the carrier polym...

Dissolution Behavior of an Amorphous Solid Dispersion in Surfactant Containing Media

G. Ma, B. S. Levine, D. J. Lavrich Merck & Co., Inc. Purpose Amorphous solid dispersions have been increasingly used to enhance the bioavailability for poorly soluble drugs. Dissolution method development for these formulations has faced challenges due to their unstable super saturation state in aqueous media. Whether the dissolution sink condition should be based on API crystalline solubility ...

Surface Solid Dispersion of Glimepiride for Enhancement of Dissolution Rate

Surface solid dispersions using water-insoluble carriers like crospovidone, croscarmellose sodium, sodium starch glycolate, pre-gelatinized starch, potato starch and Avicel PH 101 were investigated to enhance the dissolution rate of the glimepiride, a poorly water insoluble drug. The effect of various carriers on dissolution profile was studied using presence absence model. The surface solid di...

dissolution enhancement of glybenclamide by solid dispersion technique